In:
Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 4, No. 11 ( 2015-10-29)
Abstract:
Flow‐mediated dilation ( FMD ) is used to assess endothelial function through changes in vascular diameter after hyperemia. High‐fat meal ( HFM ) has been shown to induce endothelial dysfunction; recent studies, however, reported conflicting results in obese African American women ( AAW ). Differences in the method used to analyze FMD may explain these discrepancies. Methods and Results In protocol 1, we assessed the time course of FMD and compared the repeatability of FMD using the individual maximum peak dilation ( FMD peak ) and the dilation at 60 seconds ( FMD 60 ). Sixteen AAW (age, 42±10.4 years; body mass index [ BMI], 39±5.8 kg/m 2 ) were studied on 2 occasions, 4 weeks apart, under fasting conditions (study 1 and study 2). In protocol 2, we used the most repeatable measurement from protocol 1 to assess changes in endothelial function after an HFM in 17 AAW (agen 42±11.1 years; BMIn 38±5.6 kg/m 2 ). We found that FMD peak was the most repeatable measurement (N=16; study 1, 5.31±3.12% and study 2, 5.80±2.91%; r =0.94). After an HFM , the baseline brachial artery diameter significantly increased at 2 hours (0.10 mm; 95% confidence interval [ CI ], 0.01–0.18; P =0.03) and at 4 hours (0.17 mm; 95% CI , 0.09–0.25; P 〈 0.001). At 2 hours, the FMD peak decreased compared with pre‐ HFM (−1.76; 95% CI , −3.55–0.02; P≤ 0.05). Conclusions The individual's maximum peak dilation after hyperemia is the most consistent measure to assess the effect of an HFM on endothelial function. Endothelial dysfunction occurred at 2 hours after an HFM in AAW . Clinical Trial Registration URL : https://clinicaltrials.gov/ Unique identifiers: NCT 01334554 and NCT 02126735.
Type of Medium:
Online Resource
ISSN:
2047-9980
DOI:
10.1161/JAHA.115.002388
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2015
detail.hit.zdb_id:
2653953-6
