In:
Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 40, No. 12 ( 2009-12), p. 3718-3724
Kurzfassung:
Background and Purpose— This study’s objective was to compare 18 F -fluoro-2-deoxyglucose positron emission tomography ( 18 F-FDG PET), CT, and MRI of carotid plaque assessment. Materials and Methods— Fifty patients with symptomatic carotid atherosclerosis underwent 18 F-FDG PET/CT and MRI. Correlations and agreement between imaging findings were assessed by Spearman and Pearson rank correlation tests, t tests, and Bland-Altman plots. Results— Spearman ρ between plaque 18 F-FDG standard uptake values and CT/MRI findings varied from −0.088 to 0.385. Maximum standard uptake value was significantly larger in plaques with intraplaque hemorrhage (1.56 vs 1.47; P =0.032). Standard uptake values did not significantly differ between plaques with an intact and thick fibrous cap and plaques with a thin or ruptured fibrous cap on MRI. (1.21 vs 1.23; P =0.323; and 1.45 vs 1.54; P =0.727). Pearson ρ between CT and MRI measurements varied from 0.554 to 0.794 ( P 〈 0.001). For lipid-rich necrotic core volume, the CT–MRI correlation was stronger in mildly (≤10%) than in severely ( 〉 10%) calcified plaques (Pearson ρ 0.730 vs 0.475). Mean difference in measurement ±95% limits of agreement between CT and MRI for minimum lumen area, volumes of vessel wall, lipid-rich necrotic core, calcifications, and fibrous tissue were 0.4±18.1 mm 2 ( P =0.744), −41.9 ±761.7 mm 3 ( P =0.450), 78.4±305.0 mm 3 ( P 〈 0.001), 180.5±625.7 mm 3 ( P =0.001), and −296.0±415.8 mm 3 ( P 〈 0.001), respectively. Conclusions— Overall, correlations between 18 F-FDG PET and CT/MRI findings are weak. Correlations between CT and MRI measurements are moderate to strong, but there is considerable variation in absolute differences.
Materialart:
Online-Ressource
ISSN:
0039-2499
,
1524-4628
DOI:
10.1161/STROKEAHA.109.564088
Sprache:
Englisch
Verlag:
Ovid Technologies (Wolters Kluwer Health)
Publikationsdatum:
2009
ZDB Id:
1467823-8
