In:
Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 44, No. 6 ( 2013-06), p. 1732-1735
Abstract:
Dilated Virchow–Robin spaces are an emerging neuroimaging biomarker, but their assessment on MRI needs standardization. Methods— We developed a rating method for dilated Virchow–Robin spaces in 4 brain regions (centrum semiovale, basal ganglia, hippocampus, and mesencephalon) and tested its reliability in a total of 125 MRI scans from 2 population-based studies. Six investigators with varying levels of experience performed the ratings. Intraclass correlation coefficients were calculated to determine intra- and interrater reliability. Results— Intrarater reliability was excellent for all 4 regions (intraclass correlation coefficient, 〉 0.8). Interrater reliability was excellent for the centrum semiovale and hippocampus (intraclass correlation coefficient, 〉 0.8) and good for the basal ganglia and mesencephalon (intraclass correlation coefficient, 0.6–0.8). This did not differ between the cohorts or experience levels. Conclusions— We describe a reliable rating method that can facilitate pathogenic and prognostic research on dilated Virchow–Robin spaces using MRI.
Type of Medium:
Online Resource
ISSN:
0039-2499
,
1524-4628
DOI:
10.1161/STROKEAHA.111.000620
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2013
detail.hit.zdb_id:
1467823-8