In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 130, No. suppl_2 ( 2014-11-25)
Abstract:
Introduction: Atrial fibrillation (AF) is well-known to be associated with mortality and morbidity after conventional cardiac surgery. In the present sub-analysis of the FRANCE 2 registry, we investigated the impact of AF on VARC-defined outcomes in patients with severe aortic stenosis undergoing transcatether aortic valve implantation (TAVI). Methods: The FRANCE 2 registry included all TAVI performed in France between January 2010 and December 2011. Analyses were performed at 2 different time points: (1) AF vs no AF, before valve implantation, and (2) AF vs no AF, after the procedure, among the survivors at day 2. Comparisons of clinical outcomes at 30 days and 1 year, between patients with and without AF, were adjusted for baseline (all analysis) and procedural (analysis 2) characteristics by multivariate analysis. Results: In total, 3875 patients whose pre-TAVI ECG was reported were included (25.8% with AF) (study population for analysis 1). Procedural success was 94% in the non-AF group and 94.5% in the AF group. Three hundred thirteen patients (8.1%) died during the first 24 hours (non-AF: 7.8%, AF: 9.2%; P=0.13); 3377 were alive at day 2 with an ECG (study population for analysis 2); 827 (24.5%) were in AF, including 164 patients with new onset AF (4.8%). The main findings concerning the clinical outcomes of the study populations are displayed in the table. The higher rate of VARC-defined combined efficacy endpoint observed in patients with AF vs those without, in both analysis, is driven by cardiovascular deaths, worsening congestive heart failure and NYHA functional status class III or IV. Conclusion: AF, before and after TAVI, is associated with a higher rate of one-year mortality and morbidity.
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/circ.130.suppl_2.13765
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2014
detail.hit.zdb_id:
1466401-X