In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, No. Suppl_1 ( 2022-11-08)
Abstract:
Introduction: Coronary artery disease (CAD) is linked to many modifiable cardiovascular risk factors (CVRF) like smoking, diabetes, hypertension, hyperlipidaemia and obesity. High Epicardial Adipose Tissue (EAT) Hounsfield Unit (HU) attenuation using Non-contrast Computed Tomography (NCCT) is associated with more inflammation. Statin is believed to stabilise coronary plaque and reduce inflammation. However, its effects on EAT volume (EATv) and EAT HU is unknown. In this study, we quantified EAT and compared total EATv, mean EAT HU and percentage of EATv within -60 to -30 HU and -70 to -30 HU between group with statin treatment (S) and group with no statin (NS) treatment in an Asian cohort. Methods: 343 patients presenting with stable chest pain and no previous known CAD were recruited. Pericardium was segmented from NCCT. EAT volume (in cm3) and mean attenuation (in HU) were quantified with -190 to -30 HU threshold within pericardium. In subanalysis, percentage of EAT volume in the HU limits of -60 to -30 and of -70 to -30 were calculated. EAT parameters were compared between S group and NS group, adjusting for hypertension, hyperlipidemia, diabetes and smoking history. Results: The cohort comprised 343 patients (M:F 65%:35%; mean age 59±10 years old), with prevalence of hypertension (54%), hyperlipidemia (74%) and diabetes (21%), and smoking (14%). Median coronary artery calcium score was 96.0 (21.0-324.0). Mean EAT HU was significantly lower in S than NS group (p=0.024). Percentage of total EAT within the -60 to -30 HU range was also significantly lower among S than NS (p = 0.026). This was also observed using -70 to -30 HU range (p = 0.025). EATv was not significantly different between S and NS groups (p = 0.159). Conclusions: Patients on statin treatment showed lower EAT attenuation, with lower EAT HU and percentage of EAT volume within the HU ranges of -60 to -30 and -70 to -30. This suggests that statin use is associated with reduced EAT inflammation independent of EAT volume.
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/circ.146.suppl_1.11812
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2022
detail.hit.zdb_id:
1466401-X
