In:
Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 55, No. Suppl_1 ( 2024-02)
Kurzfassung:
Background: The Brain Care Score (BCS) was developed through a modified Delphi process with practitioners and patients for implementation into primary care to stimulate behavioral changes and lifestyle choices to sustainably reduce the incidence of dementia and stroke ( Fig 1) . Methods: To assess its validity as associated with incidence of dementia and stroke, the BCS was derived from the UK Biobank (UKB) baseline evaluation (2006-2010) for participants aged 40-69. Cox proportional hazards regression were used to estimate associations between the BCS and incident dementia and stroke, adjusted for sex, and stratified by age groups at baseline. Findings: The BCS (median: 12; IQR:11-14) was calculated for 398,990 UKB participants (mean age: 57; females: 54%). There were 5,354 incidents of dementia and 7,259 incidents of stroke during a median follow-up of 12.5 years. On average, a 5-point increase in baseline BCS was associated with a substantial significant decrease in dementia incidence (for those aged 〈 50 years: HR: 0.41 [95%CI: 0.28-0.60], aged 50-59: HR: 0.68 [95%CI: 0.58-0.80] , and aged 〉 59 (HR: 0.92 [95%CI: 0.86-0.98]) as well as stroke incidence (for those aged 〈 50 years: HR: 0.52 [95%CI: 0.44-0.61], aged 50-59: HR: 0.48 [95%CI: 0.44-0.53] , and aged 〉 59: HR: 0.67 [95%CI: 0.63-0.71]) (Fig 2). Interpretation: The BCS at baseline is strongly associated with risk of dementia and stroke in the UKB. Future research should include investigating the adaptability and implementation of the BCS for patients and providers into routine care worldwide.
Materialart:
Online-Ressource
ISSN:
0039-2499
,
1524-4628
DOI:
10.1161/str.55.suppl_1.WMP18
Sprache:
Englisch
Verlag:
Ovid Technologies (Wolters Kluwer Health)
Publikationsdatum:
2024
ZDB Id:
1467823-8
