In:
Network Neuroscience, MIT Press, Vol. 2, No. 3 ( 2018-09), p. 381-396
Kurzfassung:
Author Summary There is emerging evidence that the flexible network structure of the brain is related to activity within the ascending arousal systems of the brain, such as the noradrenergic locus coeruleus. Here, we explored the role of catecholaminergic activity on network architecture by analyzing the graph structure of the brain measured using functional MRI following the administration of atomoxetine, a selective noradrenaline reuptake inhibitor. We estimated functional network topology in two double-blind, placebo-controlled datasets: one from the resting state and another from a parametric N-back task. Our results demonstrate that the nature of catecholaminergic network reconfiguration is differentially related to cognitive state and provide confirmatory evidence for the hypothesis that the functional network signature of the brain is sensitive to the ascending catecholaminergic arousal system.
Materialart:
Online-Ressource
ISSN:
2472-1751
DOI:
10.1162/netn_a_00042
Sprache:
Englisch
Verlag:
MIT Press
Publikationsdatum:
2018
ZDB Id:
2900481-0
