In:
Network Neuroscience, MIT Press, Vol. 2, No. 4 ( 2018-10), p. 464-480
Abstract:
Author Summary Learning a new motor skill prompts immediate reconfigurations of distributed brain networks followed by adaptive changes in intrinsic brain circuits related to synaptic plasticity. Here, we identify global brain network properties and a cerebellar-cortical functional subnetwork that are both significantly associated with motor learning ability in a previously trained visuomotor task in humans. We further show that the associated functional subnetwork connectivity but not the global brain network properties are susceptible to ketamine. Our findings suggest a distinct functional role for learning-related global versus local network metrics and support the idea of a preferential susceptibility of learning-associated subnetworks to N-methyl-d-aspartate antagonist and plasticity-related consolidation effects.
Type of Medium:
Online Resource
ISSN:
2472-1751
DOI:
10.1162/netn_a_00045
Language:
English
Publisher:
MIT Press
Publication Date:
2018
detail.hit.zdb_id:
2900481-0