In:
Journal of Biomedical Nanotechnology, American Scientific Publishers, Vol. 18, No. 2 ( 2022-02-01), p. 571-580
Kurzfassung:
Intranasal administration, which can bypass the blood–brain barrier (BBB), is widely recognized as a promising strategy for high-efficiency drug delivery to the brain. Herein, for the purpose of effectively delivering drugs to the brain via intranasal administration, glutathione
(GSH)-modified gellan gum (GSH-GG) with ion/temperature dual responsive properties was synthesized and encapsulated on galanthamine hydrobromide (GH)-loaded liposomes (GH-Lipo) for effective GH delivery to the brain (GH-Lipo@GSH-GG). Our results demonstrated tha t GSH-GG greatly decreased the
gelation temperature of GG from 44.0 °C to 22.1 °C without compromising its ion responsiveness. Moreover, GSH-GG had a good protection ability for GH-loaded liposomes without affecting its drug release. Most importantly, the finally obtained GH-Lipo@GSHGG showed acceptable targeted delivery of GH to the brain upon in vivo administration. Therefore, this formulation can be employed as a potential delivery system in nasal-to-brain delivery.
Materialart:
Online-Ressource
ISSN:
1550-7033
DOI:
10.1166/jbn.2022.3253
Sprache:
Englisch
Verlag:
American Scientific Publishers
Publikationsdatum:
2022
