In:
Journal of Biomaterials and Tissue Engineering, American Scientific Publishers, Vol. 9, No. 10 ( 2019-12-01), p. 1403-1407
Kurzfassung:
To explore the association of apolipoprotein E polymorphism with Alzheimer's disease (AD), so as to provide possible research value for potential targeted therapy. 120 AD patients and 50 healthy volunteers were enrolled to extract fasting blood samples. ApoE gene polymorphism and blood
lipids were tested in blood. ApoE gene and genotype frequency between AD group and control group were compared by PCR and sequencing methods. MMSE, CDR, and BPSD were used to determine the intelligence. ApoE genotype was detected by DNA microarray. ɛ 4 carrier accounted for 45%
in AD group, which was significantly elevated compared with control group (12%) ( P 〈 0.05). TG, TC, and LDL-C levels were increased, while HDL-C was reduced in ɛ 4 allele carriers (all P 〈 0.05). The MMSE scores of ApoE ɛ 4 genotype carriers in AD
group were markedly lower than those of nonApoE ɛ 4 genotype carriers ( P 〈 0.05) and control ( P 〈 0.01). The proportion of dementia in ApoE ɛ 4 genotype carriers from AD group was apparently higher than the ɛ 4 gene non-carriers ( P 〈 0.05). The ApoE ɛ 4 gene is an AD risk factor. The changes of genotype and frequency of ApoE ɛ 4 gene are the main factors leading to abnormal lipid metabolism in AD patients, suggesting that ApoE ɛ 4 gene detection might be helpful for the early diagnosis
and treatment of AD.
Materialart:
Online-Ressource
ISSN:
2157-9083
DOI:
10.1166/jbt.2019.2148
Sprache:
Englisch
Verlag:
American Scientific Publishers
Publikationsdatum:
2019
