In:
Angiology, SAGE Publications, Vol. 66, No. 1 ( 2015-01), p. 25-35
Kurzfassung:
We studied the in vivo effects of estradiol on size and biochemical parameters of cardiomyocytes in pathophysiological conditions such as obesity and insulin resistance. Male Wistar rats were normally fed (controls, n = 7) or fed with high-fat diet (obese, n = 14). Half of the obese rats (obese + estradiol, n = 7) were treated with a single dose of estradiol (40 μg/kg, intraperitoneally) and 24 hours after treatment all the rats were killed. Estradiol in vivo in obese rats resulted in a significant increase in protein kinase B (Akt) activation ( P 〈 .05) and decrease in heart mass ( P 〈 .05), ratio of the heart mass/body mass ( P 〈 .05), transverse diameters of cardiomyocytes ( P 〈 .001), concentration of serum high-sensitivity C-reactive protein ( P 〈 .001), and total cholesterol ( P 〈 .01) compared with obese nontreated rats. Our results suggest that estradiol in obese/IR rats affects the size of cardiomyocytes and its actions lead in vivo to a reduction in obesity-induced cardiac hypertrophy, via Akt.
Materialart:
Online-Ressource
ISSN:
0003-3197
,
1940-1574
DOI:
10.1177/0003319713514477
Sprache:
Englisch
Verlag:
SAGE Publications
Publikationsdatum:
2015
ZDB Id:
2065911-8