In:
Angiology, SAGE Publications, Vol. 70, No. 2 ( 2019-02), p. 141-159
Kurzfassung:
Cardiovascular (CV) risk in type 1 diabetes mellitus (T1DM) is increased. In this study, we evaluated the differences in major markers of CV risk between patients with T1DM and healthy controls by a systematic review and meta-analysis. Literature from PubMed, EMBASE, and The Cochrane Library comparing CV risk markers between patients with T1DM and controls was obtained. The overall standard mean differences (SMDs) of carotid intima–media thickness (cIMT), endothelium-dependent flow-mediated dilation (FMD%), carotid-femoral pulse wave velocity (cf-PWV), and glyceryl trinitrate-mediated dilatation (GTN%) with its 95% confidence interval (CI) between patients with T1DM and control groups were calculated using fixed-effect or random-effect model. Heterogeneity was evaluated using the Cochran Q and I 2 statistics. The results showed that patients with T1DM had a significantly greater cIMT (SMD: 0.89; 95% CI, 0.69-1.09; P 〈 .001), significantly lower FMD% (SMD: −1.45%; 95% CI, −1.74 to −1.17; P 〈 .001), significantly increased cf-PWV (SMD: 0.57; 95% CI, 0.03-1.11; P 〈 .001), and significantly decreased GTN% (SMD: −1.11; 95% CI, −1.55 to −0.66; P 〈 .001) than controls. Our results support the current evidence for an elevated CV burden in patients with T1DM and affirm the clinical utility of markers of subclinical atherosclerosis in the management of these patients.
Materialart:
Online-Ressource
ISSN:
0003-3197
,
1940-1574
DOI:
10.1177/0003319718787366
Sprache:
Englisch
Verlag:
SAGE Publications
Publikationsdatum:
2019
ZDB Id:
2065911-8