In:
Angiology, SAGE Publications, Vol. 50, No. 6 ( 1999-06), p. 473-478
Abstract:
To evaluate the physiological basis for suboptimal peak exercise oxygen consumption (VO 2 p) observed in the early stage of hypertension, 25 WHO Stage I hypertensive men with normal left ventricular mass and 10 healthy control subjects of equivalent age underwent the maximal cardiopulmonary exercise test with contemporary measurement of cardiac output with Tc99m angiocardiography. At peak exercise hypertensive patients had lower VO 2 p (p 〈 0.045) and cardiac output (p 〈 0.014) and higher vascular resis tance (p 〈 0.010) than controls. At multiple regression analysis VO 2 was positively related to cardiac output in controls ( r = 0.80, p 〈 0.02), whereas in hypertensives the best (negative) correlation was observed with peripheral vascular resistance ( r = -0.72, p 〈 0.04). Thus reduced cardiopulmonary function during physical exercise in hyperten sives seems to be mainly related to impaired peripheral vascular autoregulation.
Type of Medium:
Online Resource
ISSN:
0003-3197
,
1940-1574
DOI:
10.1177/000331979905000605
Language:
English
Publisher:
SAGE Publications
Publication Date:
1999
detail.hit.zdb_id:
2065911-8