In:
Alternatives to Laboratory Animals, SAGE Publications, Vol. 19, No. 3 ( 1991-07), p. 338-343
Abstract:
Single linear regression analysis was used for chemicals of the MEIC (multicentre evaluation of in vitro cytotoxicity) project, to obtain a correlation between in vitro cytotoxicity determined in various test systems, according to data from the literature, and their lipophilicity. A linear correlation coefficient of 0.76 was determined between the IC50x¯ values (geometrical mean of two or more IC50 values per substance) of 29 MEIC substances and their octanol/water partition coefficient (owp). Since the MEIC substances were selected from a broad spectrum of structurally unrelated classes of chemicals, it may be possible to make close predictions of the general in vitro cytotoxicities of chemicals from their owp coefficients.
Type of Medium:
Online Resource
ISSN:
0261-1929
,
2632-3559
DOI:
10.1177/026119299101900307
Language:
English
Publisher:
SAGE Publications
Publication Date:
1991
detail.hit.zdb_id:
2390905-5
detail.hit.zdb_id:
605800-0
SSG:
12,22