In:
Alternatives to Laboratory Animals, SAGE Publications, Vol. 24, No. 4 ( 1996-08), p. 541-546
Abstract:
Cultures of three murine cell lines derived from fetal mouse liver (FL, FLT3 and FLT5) were treated with benzo[a]pyrene to eva luate their ability to activate promutagens. DNA adducts were detected in all three cell lines when they were treated with the major active metabolite of benzo[a]pyrene, benzo[a] pyrene diolepoxide. DNA adducts were also produced in FL and FLT3 cells when they were treated with the promutagen, benzo[a]pyrene, while treatment of FLT5 cells resulted in very few DNA adducts. In treated FL and FLT3 cells, the most evident adduct spot detected showed a chromatographic position similar to that of the main adduct formed in cells treated with (±)-r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydro-benzo[a] pyrene.
Type of Medium:
Online Resource
ISSN:
0261-1929
,
2632-3559
DOI:
10.1177/026119299602400413
Language:
English
Publisher:
SAGE Publications
Publication Date:
1996
detail.hit.zdb_id:
2390905-5
SSG:
12,22