In:
Journal of Psychopharmacology, SAGE Publications, Vol. 2, No. 1 ( 1988-01), p. 13-18
Abstract:
Corticotropin-releasing factor immunoreactivity (CRF-I) was measured in cortical brain tissue obtained at post-mortem from 12 suicide victims with clear evidence of depressive illness and 12 age-matched and sex-matched control subjects dying by natural causes. There were no significant differences in mean CRF-I concentrations in frontal, temporal, motor and parietal cortex between the total suicide group, or the eight drug-free suicides and their matched controls. These findings suggest that cortical CRF-I concentrations are unaltered in depressive illness and are discussed in relation to recent reports of elevated CRF-I con centrations in the cerebrospinal fluid of depressed patients.
Type of Medium:
Online Resource
ISSN:
0269-8811
,
1461-7285
DOI:
10.1177/026988118800200103
Language:
English
Publisher:
SAGE Publications
Publication Date:
1988
detail.hit.zdb_id:
2028926-1
