In:
Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 36, No. 4 ( 2016-04), p. 702-708
Abstract:
The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging and positron emission tomography with 3′-deoxy-3′-[ 18 F]fluorothymidine and [ 11 C]PK11195 at 2, 7, and 14 days following cerebral ischemia in TLR4 +/+ and TLR4 −/− mice. MRI showed similar infarction volumes in both groups. Despite this, positron emission tomography with 3′-deoxy-3′-[ 18 F]fluorothymidine and [ 11 C]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4 −/− mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of toll-like receptor 4 after cerebral ischemia.
Type of Medium:
Online Resource
ISSN:
0271-678X
,
1559-7016
DOI:
10.1177/0271678X15627657
Language:
English
Publisher:
SAGE Publications
Publication Date:
2016
detail.hit.zdb_id:
2039456-1