In:
Acta Radiologica, SAGE Publications, Vol. 64, No. 2 ( 2023-02), p. 572-580
Abstract:
Quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) may have the potential to reflect angiogenesis and proliferation of pulmonary neoplasms. Purpose To verify whether DCE-MRI can identify pulmonary neoplasm property and evaluate the correlation of DCE-MRI perfusion parameters with microvessel density (MVD) and Ki-67 in lung cancer. Material and Methods This study enrolled 65 patients with one pulmonary neoplasm who underwent computed tomography-guided percutaneous lung biopsy with pathological diagnosis (43 malignant, 22 benign; mean age = 59.71 ± 11.72 years). All patients did DCE-MRI before biopsy. Quantitative MRI parameters including endothelial transfer constant (K trans ), flux rate constant (K ep ), and fractional extravascular extracellular space (EES) volume (V e ) were calculated by extended Tofts linear model. MVD was evaluated by CD34-expressing tumor vessels. Proliferation was assessed by Ki-67 staining. The correlations of parameters with MVD and Ki-67 expression were analyzed. Results K trans and K ep values were significantly increased in malignant lesions compared to benign lesions ( P = 0.001 and 0.022, respectively), whereas no statistical difference in V e was found. The CD34 expression was positively correlated to K trans ( r = 0.608; P = 0.004) and K ep ( r = 0.556; P = 0.001). Subsequent subtype analyses also showed positive correlations of K trans and K ep with MVD in adenocarcinoma group ( r = 0.550 and 0.563; P = 0.012 and 0.015, respectively). No significant correlation was found between these parameters and Ki-67. Conclusion K trans and K ep may distinguish benign and malignant pulmonary neoplasm. K trans and K ep , with their positive correlation to MVD, can be used as non-invasive parameters reflecting lung cancer angiogenesis.
Type of Medium:
Online Resource
ISSN:
0284-1851
,
1600-0455
DOI:
10.1177/02841851221088581
Language:
English
Publisher:
SAGE Publications
Publication Date:
2023
detail.hit.zdb_id:
2024579-8
