In:
The International Journal of Artificial Organs, SAGE Publications, Vol. 25, No. 3 ( 2002-03), p. 210-216
Abstract:
An in vitro set-up has been designed to study the hydraulic permeability of hollow fiber dialysers. Forward and reverse dialysate ultrafiltration were determined using both sterile dialysers and samples with a protein layer settled on the membrane (Fresenius F6, F8, F60 and F80). The ultrafiltration coefficient K UF (ml/h.mmHg) was calculated as the ratio of volumetrical flow (Q UF ) and transmembrane pressure (TMP) measurements. The protein layer on the membrane was induced either by recirculating human plasma through the dialysers (in vitro) or by a standard hemodialysis session (in vivo). K UF is largely independent of TMP up to 600mmHg (low flux) and 60mmHg (high flux) for forward and reverse flow. In sterile dialysers, backfiltration yields a significantly different K UF except for the F80. An in vitro induced protein layer on the membrane decreases K UF 15–30% (forward) and 4–12% (backward) in low flux and 45–70% (forward) and 65–73% (backward) in high flux dialysers.
Type of Medium:
Online Resource
ISSN:
0391-3988
,
1724-6040
DOI:
10.1177/039139880202500307
Language:
English
Publisher:
SAGE Publications
Publication Date:
2002
detail.hit.zdb_id:
1474999-3
