In:
Journal of Bioactive and Compatible Polymers, SAGE Publications, Vol. 28, No. 6 ( 2013-11), p. 621-636
Abstract:
Poly(butylene-carbonate) is a potential alternative to poly(ε-caprolactone) for biomedical application. Although mechanical properties of porous poly(butylene-carbonate) membranes were inferior to poly(ε-caprolactone), its contact angles (47.41° ± 1.17°) were lower than poly(ε-caprolactone) (77.24° ± 0.54°) (p 〈 0.001). It degraded faster than poly(ε-caprolactone) during a 10-week in vitro experiment (p 〈 0.01). Moreover, it had excellent bioactivity during simulated body fluid immersion. Cell spreading on poly(butylene-carbonate) was better than that on poly(ε-caprolactone). Cell behavior tests including cytotoxicity, proliferation, and differentiation were performed. The poly(butylene-carbonate) is more compatible with cells and promotes cell differentiation. In vivo, the defects covered by poly(butylene-carbonate) and poly(ε-caprolactone) membranes had a similar degree of regeneration at 4 weeks. It was concluded that poly(butylene-carbonate) could potentially be used to guide bone regeneration, and it is a potential new biodegradable polymer.
Type of Medium:
Online Resource
ISSN:
0883-9115
,
1530-8030
DOI:
10.1177/0883911513509471
Language:
English
Publisher:
SAGE Publications
Publication Date:
2013
detail.hit.zdb_id:
2073790-7