In:
Antiviral Chemistry and Chemotherapy, SAGE Publications, Vol. 14, No. 4 ( 2003-08), p. 177-182
Kurzfassung:
The synthesis of novel substituted 3-aralkylth-iomethylimidazo[1,2- b]pyridazines is reported. All of the synthesized compounds are devoid of antiviral activity against the replication of human immunodeficiency virus. However, compounds 6-chloro-8-methyl-3-phenethylthioimidazo[1,2- b] pyridazine and 6-chloro-2-methyl-3-phenethyl-thioimidazo[1,2- b]pyridazine are potent inhibitors of the replication of human cytomegalovirus in vitro, while compounds 6-chloro-2-methyl-3-benzylthiomethylimidazo[1,2- b] pyridazine and 6-chloro-2-methyl-3-phenethyl-thioimidazo[1,2- b]pyridazineare inhibitors of the replication of varicella-zoster virus. The results presented here suggest that compound 10 should be considered as a new lead in the development of antiviral agents.
Materialart:
Online-Ressource
ISSN:
2040-2066
,
2040-2066
DOI:
10.1177/095632020301400402
Sprache:
Englisch
Verlag:
SAGE Publications
Publikationsdatum:
2003
ZDB Id:
2130088-4