In:
Tumor Biology, IOS Press, Vol. 39, No. 5 ( 2017-05), p. 101042831770164-
Abstract:
Accumulating evidence indicated that aberrantly expressed microRNAs play critical roles in the initiation and progression of human cancers. However, the underlying functions of miR-493 in human melanoma remains unknown. Here, our study found that miR-493 expression was downregulated in human melanoma tissues and cells. Overexpression of miR-493 suppressed cell proliferation and cell cycle in human melanoma cell line A375. IRS4 was defined as a target for downregulation by miR-493 and was confirmed by luciferase assay. We also found that knockdown of IRS4 counteracted the proliferation promotion by miR-493 inhibitor. In summary, these results demonstrated that miR-493 acts as a tumor suppressor and inhibits cell proliferation and cell cycle in human melanoma by directly targeting IRS4.
Type of Medium:
Online Resource
ISSN:
1010-4283
,
1423-0380
DOI:
10.1177/1010428317701640
Language:
English
Publisher:
IOS Press
Publication Date:
2017
detail.hit.zdb_id:
605825-5
detail.hit.zdb_id:
1483579-4
SSG:
12