In:
Journal of International Medical Research, SAGE Publications, Vol. 36, No. 2 ( 2008-03), p. 289-295
Abstract:
Insulin resistance (IR), IR treated with vitamin D, IR treated with 1α-hydroxyvitamin D (1α-(OH)D), type 2 diabetes mellitus (T2DM), T2DM treated with vitamin D and T2DM treated with 1a-(OH)D were studied in animal models using aged Wistar rats. Glucose infusion rates and levels of urinary albumin (UA), serum 25-hydroxyvitamin D (25-(OH)D) and 1, 25-dihydroxyvitamin D (1, 25-(OH) 2 D) were measured. T2DM rats had higher UA than IR or normal rats, and levels of 25-(OH)D in all models were similar. IR rats had higher 1, 25-(OH) 2 D levels than T2DM rats, and had lower 1, 25-(OH) 2 D levels than normal rats. Treating IR or T2DM rats with vitamin D had no effect on 25-(OH)D or 1, 25-(OH) 2 D. Administration of 1α-(OH)D significantly increased 1, 25-(OH) 2 D in IR rats to above-normal levels, and significantly increased 1, 25-(OH) 2 D in T2DM rats to normal levels. In IR or T2DM, abnormal vitamin D metabolism is characterized by 1, 25-(OH) 2 D deficiency and is related to renal injury.
Type of Medium:
Online Resource
ISSN:
0300-0605
,
1473-2300
DOI:
10.1177/147323000803600211
Language:
English
Publisher:
SAGE Publications
Publication Date:
2008
detail.hit.zdb_id:
2082422-1