In:
Clinical Trials, SAGE Publications, Vol. 19, No. 1 ( 2022-02), p. 116-118
Abstract:
The use of the controlled human infection model to facilitate product development and to advance understanding of host-pathogen interactions is of increasing interest. While administering a virulent (or infective) organism to a susceptible host necessitates an ongoing evaluation of safety and ethical considerations, a central theme in conducting these studies in a safe and ethical manner that yields actionable data is their conduct in facilities well-suited to address their unique attributes. To that end, we have developed a framework for evaluating potential sites in which to conduct inpatient enteric controlled human infection model to ensure consistency and increase the likelihood of success.
Type of Medium:
Online Resource
ISSN:
1740-7745
,
1740-7753
DOI:
10.1177/17407745211052473
Language:
English
Publisher:
SAGE Publications
Publication Date:
2022
detail.hit.zdb_id:
2159773-X