In:
Natural Product Communications, SAGE Publications, Vol. 7, No. 10 ( 2012-10), p. 1934578X1200701-
Abstract:
Croton argyrophylloides Muell. Arg. is widely used in Brazilian folk medicine to treat diabetes and venereal diseases. This study examined the acute toxicity and cytotoxicity of the essential oil of C. argyrophylloides(EOCA). In addition, vascular effects of the EOCA have been examined. In mice, an oral acute toxicity test revealed that EOCA could be considered as a non toxic essential oil since it showed a very high LD 50 (9.84 ± 0.01 g/kg). In the brine shrimp ( Artemia salina) cytotoxic assay, the LC 50 value of EOCA was 275 [165-534] μg/mL. EOCA (1-1000 μg/mL) relaxed isolated endothelium-intact aortic rings precontracted with phenylephrine with an IC 50 value of 126.7 [89.8-163.7] μg/mL. In rat mesenteric bed preparations precontracted with phenylephrine, EOCA (1-300 μg/mL) also induced a reversible, vasodilator effect with an IC 50 value of 46.0 [33.3-58.7] μg/mL. It is concluded that EOCA is a very interesting agent from the point of view of the possibility of therapeutic application. This is because, whilst showing a very small acute toxicity, EOCA also showed maximal efficacy as a vascular antispasmodic agent with a pharmacological potency similar to that of other Croton species essential oils.
Type of Medium:
Online Resource
ISSN:
1934-578X
,
1555-9475
DOI:
10.1177/1934578X1200701040
Language:
English
Publisher:
SAGE Publications
Publication Date:
2012
detail.hit.zdb_id:
2430442-6
SSG:
15,3
