In:
Journal of the International Association of Providers of AIDS Care (JIAPAC), SAGE Publications, Vol. 16, No. 4 ( 2017-07), p. 315-320
Abstract:
To evaluate efficacy and safety of 20 000 IU cholecalciferol weekly in HIV-infected patients. Methods: Longitudinal data for 243 HIV-infected patients with paired 25-OH-vitamin D3 values for the same month in 2 consecutive years were stratified by the initiation of supplementation in this retrospective study. Results: After 1 year of administration of cholecalciferol 20 000 IU weekly, about 78% of patients with initial vitamin D level 〈 20 µg/L achieved vitamin D levels 〉 20 µg/L and 42% achieved levels 〉 30 µg/L. Supplemented patients with baseline vitamin D levels 〈 20 µg/L showed a significant risk reduction for hypocalcemia ( P = .006; risk difference: 20.8%) and a significantly lower increase in alkaline phosphatase (AP) compared to those in the nonsubstituted group. Conclusion: The dose of 20 000 IU of cholecalciferol once weekly was found to be safe and effective. Normalization of vitamin D levels within 1 year was observed in 42% to 75% of the patients.
Type of Medium:
Online Resource
ISSN:
2325-9582
,
2325-9582
DOI:
10.1177/2325957417702487
Language:
English
Publisher:
SAGE Publications
Publication Date:
2017
detail.hit.zdb_id:
2709037-1