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Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML

Chaturvedi, Anuhar ; Araujo Cruz, Michelle Maria ; Jyotsana, Nidhi ; [et al.]

American Society of Hematology ; 2013

In: Blood Vol. 122, No. 16 ( 2013-10-17), p. 2877-2887

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In: Blood, American Society of Hematology, Vol. 122, No. 16 ( 2013-10-17), p. 2877-2887

Abstract: IDH1 promotes leukemogenesis in vivo in cooperation with HoxA9. Pharmacologic inhibition of mutant IDH1 efficiently inhibits AML cells of IDH1-mutated patients but not of normal CD34+ bone marrow cells.

Type of Medium: Online Resource

ISSN: 0006-4971 , 1528-0020

URL: Article

DOI: 10.1182/blood-2013-03-491571

RVK:

XA 33000

RVK:

XA 10000

Language: English

Publisher: American Society of Hematology

Publication Date: 2013

detail.hit.zdb_id: 1468538-3

detail.hit.zdb_id: 80069-7

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Kooperativer Bibliotheksverbund

Berlin Brandenburg