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Abnormally differentiated CD4+ or CD8+ T cells with phenotypic and genetic features of double negative T cells in human Fas deficiency

Rensing-Ehl, Anne ; Völkl, Simon ; Speckmann, Carsten ; [weitere]

American Society of Hematology ; 2014

In: Blood Vol. 124, No. 6 ( 2014-08-07), p. 851-860

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Details

In: Blood, American Society of Hematology, Vol. 124, No. 6 ( 2014-08-07), p. 851-860

Kurzfassung: Lack of KLRG1 and T-bet expression is a unique feature of DNT and subsets of single positive T cells in ALPS patients. Genetic, phenotypic, and transcriptional evidence indicates that DNT in ALPS patients derive from both CD4+ and CD8+ T cells.

Materialart: Online-Ressource

ISSN: 0006-4971 , 1528-0020

URL: Article

DOI: 10.1182/blood-2014-03-564286

RVK:

XA 33000

RVK:

XA 10000

Sprache: Englisch

Verlag: American Society of Hematology

Publikationsdatum: 2014

ZDB Id: 1468538-3