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Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition

Jacque, Nathalie ; Ronchetti, Anne Marie ; Larrue, Clément ; [et al.]

American Society of Hematology ; 2015

In: Blood Vol. 126, No. 11 ( 2015-09-10), p. 1346-1356

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In: Blood, American Society of Hematology, Vol. 126, No. 11 ( 2015-09-10), p. 1346-1356

Abstract: Genetic- or compound CB-839–induced GAC inhibition reduces OXPHOS and has antileukemic activity in AML. GAC inhibition synergizes with BCL-2 inhibition by compound ABT-199.

Type of Medium: Online Resource

ISSN: 0006-4971 , 1528-0020

URL: Article

DOI: 10.1182/blood-2015-01-621870

RVK:

XA 33000

RVK:

XA 10000

Language: English

Publisher: American Society of Hematology

Publication Date: 2015

detail.hit.zdb_id: 1468538-3

detail.hit.zdb_id: 80069-7

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Kooperativer Bibliotheksverbund

Berlin Brandenburg