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Haploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms

Emadali, Anouk ; Hoghoughi, Neda ; Duley, Samuel ; [weitere]

American Society of Hematology ; 2016

In: Blood Vol. 127, No. 24 ( 2016-06-16), p. 3040-3053

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In: Blood, American Society of Hematology, Vol. 127, No. 24 ( 2016-06-16), p. 3040-3053

Kurzfassung: NR3C1 haploinsufficiency is found in patients with a plasmacytoid dendritic cell neoplasm characterized by very poor clinical outcome. Overexpression of lincRNA-3q is a consistent feature of malignant cells in these patients and can be abrogated by BET protein inhibition.

Materialart: Online-Ressource

ISSN: 0006-4971 , 1528-0020

URL: Article

DOI: 10.1182/blood-2015-09-671040

RVK:

XA 33000

RVK:

XA 10000

Sprache: Englisch

Verlag: American Society of Hematology

Publikationsdatum: 2016

ZDB Id: 1468538-3