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Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms

Lykken, Jacquelyn M. ; Horikawa, Mayuka ; Minard-Colin, Veronique ; [et al.]

American Society of Hematology ; 2016

In: Blood Vol. 127, No. 15 ( 2016-04-14), p. 1886-1895

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In: Blood, American Society of Hematology, Vol. 127, No. 15 ( 2016-04-14), p. 1886-1895

Abstract: A preclinical model system was developed to define the molecular landscape dictating lymphoma resistance to immunotherapy. This system revealed that Gal-1 significantly inhibits CD20 immunotherapy within the lymphoma microenvironment in vivo.

Type of Medium: Online Resource

ISSN: 0006-4971 , 1528-0020

URL: Article

DOI: 10.1182/blood-2015-11-681130

RVK:

XA 33000

RVK:

XA 10000

Language: English

Publisher: American Society of Hematology

Publication Date: 2016

detail.hit.zdb_id: 1468538-3