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Phase 1 studies of central memory–derived CD19 CAR T–cell therapy following autologous HSCT in patients with B-cell NHL

Wang, Xiuli ; Popplewell, Leslie L. ; Wagner, Jamie R. ; [weitere]

American Society of Hematology ; 2016

In: Blood Vol. 127, No. 24 ( 2016-06-16), p. 2980-2990

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In: Blood, American Society of Hematology, Vol. 127, No. 24 ( 2016-06-16), p. 2980-2990

Kurzfassung: TCM-derived CD19 CAR T–cell therapy is safe for treatment of poor-risk NHL patients undergoing autologous HSCT. Addition of a CD28 costimulatory domain to the CAR, plus changes to T-cell product manufacturing, resulted in improved T-cell expansion.

Materialart: Online-Ressource

ISSN: 0006-4971 , 1528-0020

URL: Article

DOI: 10.1182/blood-2015-12-686725

RVK:

XA 33000

RVK:

XA 10000

Sprache: Englisch

Verlag: American Society of Hematology

Publikationsdatum: 2016

ZDB Id: 1468538-3