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Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high-risk disease

Branford, Susan ; Wang, Paul ; Yeung, David T. ; [weitere]

American Society of Hematology ; 2018

In: Blood Vol. 132, No. 9 ( 2018-08-30), p. 948-961

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In: Blood, American Society of Hematology, Vol. 132, No. 9 ( 2018-08-30), p. 948-961

Kurzfassung: Next-generation sequencing revealed variants in cancer-associated genes at diagnosis of CML more frequently in patients with poor outcomes. All patients at BC had mutated cancer genes, including fusions, that predated BCR-ABL1 kinase domain mutations in a majority.

Materialart: Online-Ressource

ISSN: 0006-4971 , 1528-0020

URL: Article

DOI: 10.1182/blood-2018-02-832253

RVK:

XA 33000

RVK:

XA 10000

Sprache: Englisch

Verlag: American Society of Hematology

Publikationsdatum: 2018

ZDB Id: 1468538-3