In:
European Respiratory Journal, European Respiratory Society (ERS), Vol. 58, No. 3 ( 2021-09), p. 2002012-
Kurzfassung:
Prenatal vitamin D 3 supplementation has been linked to reduced risk of early-life asthma/recurrent wheeze. This protective effect appears to be influenced by variations in the 17q21 functional single nucleotide polymorphism rs12936231 of the child, which regulates the expression of ORMDL3 (ORM1-like 3) and for which the high-risk CC genotype is associated with early-onset asthma. However, this does not fully explain the differential effects of supplementation. We investigated the influence of maternal rs12936231 genotype variation on the protective effect of prenatal vitamin D 3 supplementation against offspring asthma/recurrent wheeze. Methods We determined the rs12936231 genotype of mother–child pairs from two randomised controlled trials: the Vitamin D Antenatal Asthma Reduction Trial (VDAART, n=613) and the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC 2010 , n=563), to examine the effect of maternal genotype variation on offspring asthma/recurrent wheeze at age 0–3 years between groups who received high-dose prenatal vitamin D 3 supplementation versus placebo. Results Offspring of mothers with the low-risk GG or GC genotype who received high-dose vitamin D 3 supplementation had a significantly reduced risk of asthma/recurrent wheeze when compared with the placebo group (hazard ratio (HR) 0.54, 95% CI 0.37–0.77; p 〈 0.001 for VDAART and HR 0.56, 95% CI 0.35–0.92; p=0.021 for COPSAC 2010 ), whereas no difference was observed among the offspring of mothers with the high-risk CC genotype (HR 1.05, 95% CI 0.61–1.84; p=0.853 for VDAART and HR 1.11, 95% CI 0.54–2.28; p=0.785 for COPSAC 2010 ). Conclusion Maternal 17q21 genotype has an important influence on the protective effects of prenatal vitamin D 3 supplementation against offspring asthma/recurrent wheeze.
Materialart:
Online-Ressource
ISSN:
0903-1936
,
1399-3003
DOI:
10.1183/13993003.02012-2020
DOI:
10.1183/13993003.02012-2020.Supp1
DOI:
10.1183/13993003.02012-2020.Shareable1
Sprache:
Englisch
Verlag:
European Respiratory Society (ERS)
Publikationsdatum:
2021
ZDB Id:
2834928-3
ZDB Id:
1499101-9