In:
BMC Infectious Diseases, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2006-12)
Kurzfassung:
Previous studies have indicated that a recently described anaerobic bacterium, Atopobium vaginae is associated with bacterial vaginosis (BV). Thus far the four isolates of this fastidious micro-organism were found to be highly resistant to metronidazole and susceptible for clindamycin, two antibiotics preferred for the treatment of BV. Methods Nine strains of Atopobium vaginae , four strains of Gardnerella vaginalis , two strains of Lactobacillus iners and one strain each of Bifidobacterium breve , B. longum, L. crispatus, L. gasseri and L. jensenii were tested against 15 antimicrobial agents using the Etest. Results All nine strains of A. vaginae were highly resistant to nalidixic acid and colistin while being inhibited by low concentrations of clindamycin (range: 〈 0.016 μg/ml), rifampicin ( 〈 0.002 μg/ml), azithromycin ( 〈 0.016 – 0.32 μg/ml), penicillin (0.008 – 0.25 μg/ml), ampicillin ( 〈 0.016 – 0.94 μg/ml), ciprofloxacin (0.023 – 0.25 μg/ml) and linezolid (0.016 – 0.125 μg/ml). We found a variable susceptibility for metronidazole, ranging from 2 to more than 256 μg/ml. The four G. vaginalis strains were also susceptible for clindamycin ( 〈 0.016 – 0.047 μg/ml) and three strains were susceptible to less than 1 μg/ml of metronidazole. All lactobacilli were resistant to metronidazole ( 〉 256 μg/ml) but susceptible to clindamycin (0.023 – 0.125 μg/ml). Conclusion Clindamycin has higher activity against G. vaginalis and A. vaginae than metronidazole, but not all A. vaginae isolates are metronidazole resistant, as seemed to be a straightforward conclusion from previous studies on a more limited number of strains.
Materialart:
Online-Ressource
ISSN:
1471-2334
DOI:
10.1186/1471-2334-6-51
Sprache:
Englisch
Verlag:
Springer Science and Business Media LLC
Publikationsdatum:
2006
ZDB Id:
2041550-3
