In:
BMC Medical Genetics, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2006-12)
Abstract:
The role of the Beta2-adrenoceptor (beta2-AR) Gln27Glu polymorphism in the manifestation of cardiovascular diseases is still unclear. Methods In the present study, we evaluated the potential relevance of the c.79 C 〉 G (p.Gln27Glu) polymorphism of this receptor gene for coronary artery disease (CAD) and its associated risk factors in Saudi Arabs. Genotyping was performed by PCR using the confronting two-pair primer (PCR-CTPP) method. Results In the general population group (BD) (n = 895), 68.5% were homozygous wild-type C/C, 28.3% were heterozygous C/G and 3.2% were homozygous mutant G/G. Among the CAD patients (n = 773), 50.6% were homozygous wild-type C/C, 43.6% were heterozygous C/G and 5.8% were homozygous mutant G/G, while in the angiographed control group (CON) (n = 528), 71.8% were C/C, 24.4% C/G and 3.8% G/G genotypes. These results indicate that both the C/G ( p = 〈 .001) and G/G ( p = .005) genotypes are significantly associated with CAD, when compared to the CON group. In addition, C/G ( p = 〈 .001) and G/G ( p = 〈 .001) were significantly associated with CAD, when compared to the BD group. Furthermore, stepwise logistic regression showed that the genotype [C/G ( p 〈 .001) and G/G ( p 〈 .001)] increase the risk of CAD. Conclusion These results shows that the Gln27Glu genotypes (homo- or heterozygous) of the beta2-AR may be independent predictors of severe CAD.
Type of Medium:
Online Resource
ISSN:
1471-2350
DOI:
10.1186/1471-2350-7-31
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2006
detail.hit.zdb_id:
2041359-2
