In:
BMC Cancer, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2009-12)
Kurzfassung:
The purpose of this study is to analyze the combined effects of selected p 53 and p 73 polymorphisms and their interaction with lifestyle habits on squamous cell carcinoma of the head and neck (SCCHN) risk and progression in an Italian population. Methods Two hundred and eighty-three cases and 295 hospital controls were genotyped for p 53 polymorphisms on exon 4 (Arg72Pro), intron 3 and 6, and p 73 G4C14-to-A4T14. Their association with SCCHN was estimated using a logistic regression analysis, while a multinomial logistic regression approach was applied to calculate the effect of the selected polymorphisms on SCCHN different sites (oral cavity, oropharynx, hypopharynx and larynx). We performed an haplotype analysis of the p 53 polymorphisms, and a gene-gene interaction analysis for the combined effects of p 73 G4C14-to-A4T14 and p 53 polymorphisms. Results We found a significant increased risk of SCCHN among individuals with combined p 73 exon 2 G4A and p 53 intron 3 variant alleles (OR = 2.22, 95% CI: 1.08–4.56), and a protective effect for those carrying the p 53 exon 4- p 53 intron 6 diplotype combination (OR = 0.67; 95% CI: 0.47–0.92). From the gene-environment interaction analysis we found that individuals aged 〈 45 years carrying p 73 exon 2 G4A variant allele have a 12.85-increased risk of SCCHN (95% CI: 2.10–78.74) compared with persons of the same age with the homozygous wild type genotype. Improved survival rate was observed among p 53 intron 6 variant allele carriers (Hazard Ratio = 0.51 (95% CI: 0.23–1.16). Conclusion Our study provides for the first time evidence that individuals carrying p 53 exon 4 and p 53 intron 6 variant alleles are significantly protected against SCCHN, and also shows that an additional risk is conferred by the combination of p 73 exon 2 G4C14-to-A4T14 and p 53 intron 3 variant allele. Larger studies are required to confirm these findings.
Materialart:
Online-Ressource
ISSN:
1471-2407
DOI:
10.1186/1471-2407-9-137
Sprache:
Englisch
Verlag:
Springer Science and Business Media LLC
Publikationsdatum:
2009
ZDB Id:
2041352-X
