In:
Cell Communication and Signaling, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2010-12)
Abstract:
In the past two decades, zebrafish genetic screens have identified a wealth of mutations that have been essential to the understanding of development and disease biology. More recently, chemical screens in zebrafish have identified small molecules that can modulate specific developmental and behavioural processes. Zebrafish are a unique vertebrate system in which to study chemical genetic systems, identify drug leads, and explore new applications for known drugs. Here, we discuss some of the advantages of using zebrafish in chemical biology, and describe some important and creative examples of small molecule screening, drug discovery and target identification.
Type of Medium:
Online Resource
ISSN:
1478-811X
DOI:
10.1186/1478-811X-8-11
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2010
detail.hit.zdb_id:
2126315-2
SSG:
12
