In:
Epidemiologic Perspectives & Innovations, Springer Science and Business Media LLC, Vol. 4, No. 1 ( 2007-12)
Kurzfassung:
When carefully planned and analysed, the case-cohort design is a powerful choice for follow-up studies with multiple event types of interest. While the literature is rich with analysis methods for case-cohort data, little is written about the designing of a case-cohort study. Our experiences in designing, coordinating and analysing the MORGAM case-cohort study are potentially useful for other studies with similar characteristics. The motivation for using the case-cohort design in the MORGAM genetic study is discussed and issues relevant to its planning and analysis are studied. We propose solutions for appending the earlier case-cohort selection after an extension of the follow-up period and for achieving maximum overlap between earlier designs and the case-cohort design. Approaches for statistical analysis are studied in a simulation example based on the MORGAM data.
Materialart:
Online-Ressource
ISSN:
1742-5573
DOI:
10.1186/1742-5573-4-15
Sprache:
Englisch
Verlag:
Springer Science and Business Media LLC
Publikationsdatum:
2007
ZDB Id:
2162808-7