In:
Journal of Experimental & Clinical Cancer Research, Springer Science and Business Media LLC, Vol. 29, No. 1 ( 2010-12)
Kurzfassung:
Connexin26 (Cx26) is one of the connexins (Cxs) family members which form gap junction channels. Cx26 is considered to be a tumor suppressor gene. However, recent studies revealed that over expression of Cx26 is associated with a poor prognosis in several human cancers. This study investigated the correlation between Cx26 expression and the clinicopathological features and P53 expression in colorectal cancer. Methods One hundred and fifty-three patients who underwent a curative resection were studied. Tissue samples were investigated by immunohistochemical staining using antibodies for Cx26 and P53. Moreover, apoptotic cells were detected by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) staining. Results Cx26 expression was found in 83 cases (54.2%) and P53 expression in 71 cases (46.4%). A correlation was observed between the Cx26 expression and recurrence, histology, and p53 expression (P 〈 0.05). Cx26 positive tumors had significantly longer survival than Cx26 negative tumors (P 〈 0.05). A multivariate Cox analysis demonstrated that Cx26 expression was an independent prognostic factor (P 〈 0.05). However, no significant correlation was observed between Cx26 and AI. Conclusion This study suggests that Cx26 expression is an independent prognostic factor in patients that undergo a curative resection of colorectal cancer.
Materialart:
Online-Ressource
ISSN:
1756-9966
DOI:
10.1186/1756-9966-29-79
Sprache:
Englisch
Verlag:
Springer Science and Business Media LLC
Publikationsdatum:
2010
ZDB Id:
2430698-8
