In:
Journal of the International AIDS Society, Wiley, Vol. 12, No. 1 ( 2009-02), p. 14-14
Abstract:
The overlapping drug toxicity profiles, drug‐drug interactions and complications of management of both HIV and tuberculosis (TB) in patients with advanced HIV have not been fully delineated. Methods We conducted a retrospective chart review of the outcomes of tuberculosis treatment among 69 HIV‐infected patients with TB, who were hospitalized in Masih Daneshvari Hospital in Tehran, Iran between 2002 and 2006, and who received standard category 1 (CAT‐1) regimens. Group I (N = 47) included those treated from 2002 to 2005 with highly active antiretroviral therapy (HAART) initiated after eight weeks of TB treatment for those whose CD4 count was 〈 200 cells/mm 3 . Group II (N = 22) included TB patients treated from 2005 to 2006, with HAART initiated after two weeks of TB treatment if their CD4 count was 〈 100 cells/mm 3 and eight weeks after initiation of TB treatment for those whose CD4 count was between 101 and 200 cells/mm 3 . Results There were no differences between Groups I and II with regard to: adverse drug reactions [four (8.5%) versus two (9%), p = ns]; IRIS [six (12.7%) versus three (10.7%), p = ns] ; and new opportunistic infections [eight (17.0%) versus two (9.1%), p = ns]. Death, however, occurred more frequently in Group I than in Group II [13 (27.7%) versus (4.5%), p = 0.03] , where HAART was initiated earlier. Injection of drugs was the most common route of HIV transmission in both groups (72.3% in Group I and 77.3% in Group II). Conclusion This manuscript shows that in a retrospective review of HIV/TB patients hospitalized in Tehran, improved survival was associated with earlier initiation of antiretroviral therapy in HIV/TB patients with CD4 counts of below 100 cells/mm 3 .
Type of Medium:
Online Resource
ISSN:
1758-2652
,
1758-2652
DOI:
10.1186/1758-2652-12-14
Language:
English
Publisher:
Wiley
Publication Date:
2009
detail.hit.zdb_id:
2467110-1
