In:
BMC Research Notes, Springer Science and Business Media LLC, Vol. 15, No. 1 ( 2022-09-05)
Abstract:
Omega-6 ( n -6) and omega-3 ( n -3) polyunsaturated fatty acids (PUFAs) are essential nutrients. Dietary imbalance between these PUFAs, in particular high in n -6 PUFAs and low in n -3 PUFAs ( n -6 high / n -3 low ), is common in modern society. We have previously reported that C57BL/6 mouse male offspring derived from mothers exposed to an n -6 high / n -3 low diet during the gestation had an augmented ventral midbrain dopamine system in adulthood; however, the fatty acid composition in this brain region has not yet been investigated. This follow-up study aims to characterize the fatty acid profile of the ventral midbrain of mice exposed to the n -6 high / n -3 low diet during specific life stages. Results n -6 PUFAs, especially linoleic acid, were increased in the ventral midbrain of offspring exposed to the n -6 high / n -3 low diet during the gestation compared to those exposed to a well-balanced control diet throughout life. On the other hand, n -3 PUFAs, especially docosahexaenoic acid, were decreased in the ventral midbrain of offspring exposed to the n -6 high / n -3 low diet during the gestation, lactation, or postweaning period compared to those exposed to the control diet throughout life. Thus, exposure to the n -6 high / n -3 low diet in pregnancy increases linoleic acid and that in any life stage decreases docosahexaenoic acid in the offspring's ventral midbrain.
Type of Medium:
Online Resource
ISSN:
1756-0500
DOI:
10.1186/s13104-022-06175-0
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2022
detail.hit.zdb_id:
2413336-X
