In:
EJNMMI Research, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-03-09)
Abstract:
PET/MRI hybrid imaging in pulmonary arterial hypertension (PAH) provides important prognostic information identifying patients who might benefit from early therapy escalation, as right ventricle (RV) metabolic alterations are linked with hemodynamics and might precede clinical deterioration. Now, we hypothesize that adequate PAH therapy escalation may result in reversal of unfavourable increased glucose uptake of RV, which is associated with improved prognosis. Methods Out of twenty-six initially clinically stable PAH patients who had baseline PET/MRI scans, twenty (49.9 ± 14.9 years) had second PET/MRI after 24 months. SUV RV /SUV LV ratio was used to estimate and compare cardiac glucose uptake. Occurrences of clinical endpoints (CEP), defined as death or clinical deterioration, were assessed during 48-month follow-up from baseline. Results In first 24 months of observation, sixteen patients had CEP and needed PAH therapy escalation. At follow-up visits, we observed significant improvement of RV ejection fraction (45.1 ± 9.6% to 52.4 ± 12.9%, p = 0.01), mean pulmonary artery pressure (50.5 ± 18.3 to 42.8 ± 18.6 mmHg, p = 0.03), and SUV RV /SUV LV , which tended to decrease (mean change -0.20 ± 0.74). Patients with baseline SUV RV /SUV LV value higher than 0.54 had worse prognosis in 48 months observation (log-rank test, p = 0.0007); follow up SUV RV /SUV LV 〉 1 predicted CEP in the following 24 months, regardless of previously escalated treatment. Conclusions PAH therapy escalation may influence RV glucose metabolism, what seems to be related with patients’ prognosis. PET/MRI assessment may predict clinical deterioration regardless of previous clinical course, however its clinical significance in PAH requires further studies. Importantly, even mild alterations of RV glucose metabolism predict clinical deterioration in long follow-up. Clinical Trial Registration ClinicalTrials.gov, NCT03688698, 05/01/2016, https://clinicaltrials.gov/ct2/show/study/NCT03688698?term=NCT03688698 & draw=2 & rank=1
Type of Medium:
Online Resource
ISSN:
2191-219X
DOI:
10.1186/s13550-023-00971-w
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2023
detail.hit.zdb_id:
2619892-7
