In:
Clinical Phytoscience, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2020-12)
Abstract:
This study was aimed at evaluating the hematinic effect of Spondias mombin and its protective role against the spleenotoxic effect of Phenylhydrazine (PHZ). Methods Thirty Wistar rats were randomized into 6 groups. Group A (Control) animals were neither given the extract nor PHZ. Rats in groups B and C were administered 150 mg/kg body weight and 300 mg/kg body weight doses of the extract respectively. Anemia was induced in rats in groups D and E by oral administration of 40 mg/kg body weight of PHZ and concomitantly administered 150 mg/kg body weight and 300 mg/kg body weight doses of the extract respectively. Anemia was also induced in rats in group F by administration of 40 mg/kg body weight of PHZ but without administration of the extract. Results Histology of the spleen show moderate expansion of the red pulp and contraction of lymphoid follicles in group F and mild follicular activation and sinus histiocytosis in group D. There were significant ( p 〈 0.05) increase in the weight of the spleen in group F and decrease in group C. Results also show significant (p 〈 0.05) decreases in the RBC count in group F and increases in the Mean Corpuscular Volume and Mean Corpuscular Haemoglobin in groups D and E. There was also a significant ( P 〈 0.05) decrease in the Mean Corpuscular Haemoglobin Count in group D. Conclusion This study shows the hematinic effect of Spondias mombin and its possible use in ethno-medicine in managing anemic conditions, as well as its potential in protecting against the spleenotoxic effect of PHZ.
Type of Medium:
Online Resource
ISSN:
2199-1197
DOI:
10.1186/s40816-020-00180-1
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2020
detail.hit.zdb_id:
2834057-7
