In:
European Journal of Hybrid Imaging, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2021-12)
Abstract:
The positron emission tomography (PET) radioligand 18 F-THK5351 is now used to evaluate monoamine oxidase B expression in the reactive astrogliosis seen in various central nervous diseases. Traumatic brain injury (TBI) is known to induce reactive astrogliosis in the lesion site. This is a first report to examine the spatial and temporal changes in reactive astrogliosis as evaluated by 18 F-THK5351 after a severe TBI. Case presentation A 27-year-old man suffering from a severe TBI with multiple brain contusions was examined using 18 F-THK5351 PET/CT in the subacute and chronic phases after the injury. The first PET scan, performed 46 days after the TBI, showed intense uptake of 18 F-THK5351 in and around the brain contusions. The second PET scan, performed 271 days after the TBI, showed reduced uptake of 18 F-THK5351 at the original sites of the brain contusions and increased uptakes in the white matter surrounding the contusions and the corpus callosum. The patient exhibited sustained improvement of neuropsychological impairment between the two PET examinations and remarkable recovery from the severe TBI. Conclusions There were evident temporal and spatial changes in 18 F-THK5351 uptake in the traumatized brain between the two PET examinations. These changes may have been related to the remarkable neurological recovery in this patient. The degree and distribution of reactive astrogliosis detected by 18 F-THK5351 PET may be useful in assessing pathophysiology and predicting prognosis in TBI patients.
Type of Medium:
Online Resource
ISSN:
2510-3636
DOI:
10.1186/s41824-021-00121-2
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2021
detail.hit.zdb_id:
2886512-1
