In:
British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 179, No. 6 ( 2001-12), p. 519-522
Abstract:
In previous research, lapses in dosing of paroxetine or sertraline were associated with significantly more discontinuation symptoms and deterioration of depressive symptomatology compared with fluoxetine. Aims To evaluate dosing lapses in patients chronically treated with selective serotonin reuptake inhibitors (SSRIs) in uncontrolled circumstances. Method In a prospective observational study we evaluated compliance data in chronic users of SSRIs using electronic drug exposure monitors. Results During a 3-month follow-up we found that 50/69 (72.5%) patients missed at least one dosing day and 20/69 (29.0%) missed two or more consecutive days. Conclusions About 30% of patients treated with short-acting SSRIs had dosing lapses of 2 or more days, which, as described in prior studies, is long enough to result in clinically relevant deterioration of mental status.
Type of Medium:
Online Resource
ISSN:
0007-1250
,
1472-1465
DOI:
10.1192/bjp.179.6.519
Language:
English
Publisher:
Royal College of Psychiatrists
Publication Date:
2001
detail.hit.zdb_id:
2021500-9
