In:
British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 195, No. 3 ( 2009-09), p. 218-226
Kurzfassung:
Structural brain abnormalities have been described in individuals with an
at-risk mental state for psychosis. However, the neuroanatomical underpinnings of the early and late at-risk mental state relative to
clinical outcome remain unclear. Aims To investigate grey matter volume abnormalities in participants in a
putatively early or late at-risk mental state relative to their prospective clinical outcome. Method Voxel-based morphometry of magnetic resonance imaging data from 20 people
with a putatively early at-risk mental state (ARMS–E group) and 26 people with a late at-risk mental state (ARMS–L group) as well as from 15
participants with at-risk mental states with subsequent disease transition (ARMS–T group) and 18 participants without subsequent disease
transition (ARMS–NT group) were compared with 75 healthy volunteers. Results Compared with healthy controls, ARMS–L participants had grey matter
volume losses in frontotemporolimbic structures. Participants in the ARMS–E group showed bilateral temporolimbic alterations and subtle
prefrontal abnormalities. Participants in the ARMS–T group had prefrontal alterations relative to those in the ARMS–NT group and in the healthy
controls that overlapped with the findings in the ARMS–L group. Conclusions Brain alterations associated with the early at-risk mental state may
relate to an elevated susceptibility to psychosis, whereas alterations underlying the late at-risk mental state may indicate a subsequent
transition to psychosis.
Materialart:
Online-Ressource
ISSN:
0007-1250
,
1472-1465
DOI:
10.1192/bjp.bp.108.052068
Sprache:
Englisch
Verlag:
Royal College of Psychiatrists
Publikationsdatum:
2009
ZDB Id:
2021500-9