In:
British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 206, No. 3 ( 2015-03), p. 198-205
Abstract:
Individuals with schizophrenia and people with depression both show
abnormal behavioural and neural responses when perceiving and responding to emotional stimuli, but pathology-specific differences and
commonalities remain mostly unclear. Aims To directly compare empathic responses to dynamic multimodal emotional
stimuli in a group with schizophrenia and a group with depression, and to investigate their neural correlates using functional magnetic resonance
imaging (fMRI). Method The schizophrenia group ( n = 20), the depression group
( n = 24) and a control group ( n =
24) were presented with portrait-shot video clips expressing emotion through three possible communication channels: facial expression, prosody
and content. Participants rated their own and the actor's emotional state as an index of empathy. Results Although no group differences were found in empathy ratings,
characteristic differences emerged in the fMRI activation patterns. The schizophrenia group demonstrated aberrant activation patterns during the
neutral speech content condition in regions implicated in multimodal integration and formation of semantic constructs. Those in the depression
group were most affected during conditions with trimodal emotional and trimodal neutral stimuli, in key regions of the mentalising network. Conclusions Our findings reveal characteristic differences in patients with
schizophrenia compared with those with depression in their cortical responses to dynamic affective stimuli. These differences indicate that
impairments in responding to emotional stimuli may be caused by pathology-specific problems in social cognition.
Type of Medium:
Online Resource
ISSN:
0007-1250
,
1472-1465
DOI:
10.1192/bjp.bp.113.143040
Language:
English
Publisher:
Royal College of Psychiatrists
Publication Date:
2015
detail.hit.zdb_id:
2021500-9
