In:
Annals of the New York Academy of Sciences, Wiley, Vol. 1040, No. 1 ( 2005-04), p. 89-94
Kurzfassung:
A bstract : We have used sequence hidden Markov models to identify and classify all G‐protein‐coupled receptors (GPCRs) from 13 eukaryotic genomes. We found that the 5 main families found in mammals are present before the divergence of nematodes. We also found that several classes of GPCRs are not present within the vertebrate lineage, whereas they are present in several other taxa. The superfamily of GPCRs has a very dynamic gene repertoire, as evidenced by the several lineage‐specific expansions of various families of GPCRs that we found. Further, the number of GPCRs has gradually increased with increased complexity of the organism.
Materialart:
Online-Ressource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1196/annals.1327.011
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2005
ZDB Id:
2834079-6
ZDB Id:
211003-9
ZDB Id:
2071584-5
SSG:
11
