In:
Annals of the New York Academy of Sciences, Wiley, Vol. 1031, No. 1 ( 2004-12), p. 391-394
Kurzfassung:
A bstract : In this study, we evaluated the antiproliferative effect of tocotrienols (T3) and the presence of a specific vitamin E metabolism in PC3 and LNCaP prostate cancer cells. These cell lines are able to transform tocopherols (T) and T3 in the corresponding carboxyethyl‐hydroxychromans metabolites (CEHCs). The extent of this metabolism and the inhibitory effect on cell growth followed the order of magnitude α‐T 〈 α‐T3 〈 γ‐T 〈 γ‐T3. The partial inhibition of γ‐T3 metabolism by ketoconazole did not influence cell proliferation. These early findings may suggest that the transformation of vitamin E to CEHC is mostly a detoxification mechanism useful to maintain the malignant properties of prostate cancer cells.
Materialart:
Online-Ressource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1196/annals.1331.054
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2004
ZDB Id:
2834079-6
ZDB Id:
211003-9
ZDB Id:
2071584-5
SSG:
11
